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性別* 男女

HArmonyCa 美神針

隨年齡增長，膠原蛋白、彈性纖維及透明質酸加快流失^3-5，令皮膚逐漸變薄，失去結構、彈性和柔軟度，缺乏豐盈感和支撐力，出現皺紋和鬆弛下垂⁶。

HArmonyCa 美神針是全球醫美領導廠商 Allergan Aesthetics 旗下的最新膠原產品，能3重還原初生緊緻^1,2,7，獲歐盟CE認證。利用嶄新科技糅合兩大肌膚關鍵元素 CaHA⁸ 及透明質酸⁸，高端結合雙效優點，以獨特「C-shape拉提」打法，帶來即時可見而愈漸緊緻的效果。

3 重還原初生緊緻

即時飽滿豐盈
填補凹陷位置
減淡皺紋

刺激纖維母細胞
促進膠原蛋白自我增生及重組
增厚真皮層

全面緊緻提升
重塑立體輪廓
持續長效拉提

HArmonyCa 雙效組合

CaHA微球

透過刺激纖維母細胞，促進膠原蛋白自我再生^9,11-13
新生膠原令真皮層增厚，從而改善肌膚結構並緊緻肌膚，帶來漸進而持久的拉提效果^13,14
完全可與身體相容和被分解¹¹

交聯透明質酸凝膠

肌膚細胞外基質的結構成分^15,16
結合透明質酸的彈性和凝聚力來達致拉提肌膚的效果^17,18
安全耐受性良好¹⁵

HArmonyCa 作用機制

隨年紀增長，肌膚表面出現皺紋、凹陷，面部亦逐漸失去飽滿感^4,19-21

透明質酸直達真皮下層的膠原纖維之間，立刻撐起肌膚，即現拉提緊緻^18,’

CaHA透過刺激膠原蛋白纖維增生，改善肌膚內在結構^{^,10,13}，支持自生膠原再生^9,13

緊密細緻的膠原蛋白結構逐漸在肌膚內形成，帶來持續長效拉提的效果^{12,13,14,22,’’}

HArmonyCa 持續可見的拉提效果

喚活新生膠原

由第一個星期開始^2,+

與其他CaHA產品相比，HArmonyCa一星期開始已能更高度滲透入肌膚內^{+,^}

在療程後的第2-12週，能展現更顯著及更持久的拉提效果^1,*

91.6%用家見證改善效果^23-25

用家滿意度高持續達19個月^24,25,#

療程前後效果

療程前

療程後

療程前後效果

療程前

療程後

*療程效果因人而異

^{* Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 12 weeks.}

^{+Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 8 weeks.}

^{^ Extracellular matrix components such as proteoglycans and elastin.}

^{‘Results derived from an animal model study comparing fillers.}

^{‘’ Based on results from in vitro testing.}

^{#Performance evaluation using the 5-point Likert Scale User Satisfaction Questionnaire.}

^{1. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150036. Lift capacity. July 2021}

^{2. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150040. Collagen stimulation. July 2021}

^{3. Tortora G, Derrickson B. The Integumentary System. In: Principles of Anatomy and Physiology (15th ed). Hoboken, NJ: John Wiley & Sons Inc.; 2012. Chapter 5. p144–170. ISBN 13 978-0470-56510-0, ISBN 13 978-0470-91777-0}

^{4. Weller RB et al. Skin Reactions to Light. In: Clinical Dermatology (5th ed). Oxford: Blackwell Science; 2015. Chapter 18. p258–266. ISBN 978-0-470-65952-6}

^{5. Reilly DM, Lozano J. Plast Aesthet Res. 2021;8:2}

^{6. McGrath JA and Lai-Cheong JE. Skin and its appendages. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 7. p141–161. ISBN 978-07020-5230-9.}

^{7. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine. Clinical Study Report. July 2022}

^{8. HArmonyCa IFU. 73960EU10. M049 V01. Revision December 2021}

^{9. Zerbinati N, Calligaro A. Clin Cosmet Investig Dermatol. 2018;11:29–35}

^{10. Gonzalez N, Goldberg. J. Dermatol Surg. 2019;45:547–551}

^{11. Segal T et al. 2014 – Post marketing study of safety and efficacy of Crystalys, a calcium hydroxyapatite based filler for facial soft tissue augmentation. Available at: https://www.kosmetischemedizin-online.de/uebersichtsarbeit/post-marketingstudie-zur-sicherheit-und-wirksamkeit-von-crystalys-einem-auf-calciumhydroxyapatit-basierenden-filler-fuer-die-weichteilaugmentation-im-gesicht/. Accessed July 2021;}

^{12. Berlin A et al. Dermatol Surg. 2008;34(1 Suppl):S64–67}

^{13. Gonzaga da Cunha M et al.Surg Cosmet Dermatol. 2020;12:109–117.}

^{14. The clinical effects of CaHA can last 1–3 years.}

^{15. Park S et al. Ann Dermatol. 2014;26:357–362}

^{16. Wigley CB. Integrating cells into tissues. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 2. p28–41. ISBN 978-07020-5230-9}

^{17. Borell M, et al. J Cosmet Laser Ther 2011;13:21–27}

^{18. Hee C, et al. Dermatol Surg. 2015; 41:S373–381}

^{19. De Boulle K et al. Dermatologic Surgery. 2018;44(11):1437–1448}

^{20. Prendergast PM. Anatomy of the Face and Neck. In: Shiffman MA, Di Giuseppe A. (eds.) Cosmetic Surgery: Art and Techniques. Berlin: Springer-Verlag; 2013. Chapter 2. p29–45. ISBN 978-3-6422-1836-1}

^{21. Wulc AE et al. The Anatomic Basis of Midfacial Aging. In: Hartstein ME et al (eds.) Midfacial Rejuvenation. New York: Springer-Verlag; 2012. Chapter 2. p15–28. ISBN 978-1-4614-1006-5}

^{22. Casabona G et al. Calcium hydroxylapatite microspheres provide organization into unorganized collagen networks leading to improvement of skin attractiveness. E-Poster Presentation. International Master Course on Aging Science (IMCAS) World Congress. 2020. 30 January–01 February; Paris, France.}

^{23. Performance evaluation using the Global Aesthetic Improvement Scale.}

^{24. Allergan Aesthetics. Data on File. INT-HAR-2150007. HArmonyCa Lidocaine. Clinical Study Report. March 2021.}

^{25. A post-marketing clinical follow-up of safety and performance of HArmonyCa (N=162).}

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隨年齡增長，膠原蛋白、彈性纖維及透明質酸加快流失3-5，令皮膚逐漸變薄，失去結構、彈性和柔軟度，缺乏豐盈感和支撐力，出現皺紋和鬆弛下垂6。

3 重還原初生緊緻

即時飽滿豐盈

填補凹陷位置

減淡皺紋

刺激纖維母細胞

促進膠原蛋白自我增生及重組

增厚真皮層

全面緊緻提升

重塑立體輪廓

持續長效拉提

HArmonyCa 雙效組合

CaHA微球

透過刺激纖維母細胞，促進膠原蛋白自我再生9,11-13

新生膠原令真皮層增厚，從而改善肌膚結構並緊緻肌膚，帶來漸進而持久的拉提效果13,14

完全可與身體相容和被分解11

交聯透明質酸凝膠

肌膚細胞外基質的結構成分15,16

結合透明質酸的彈性和凝聚力來達致拉提肌膚的效果17,18

安全耐受性良好15

HArmonyCa 作用機制

隨年紀增長，肌膚表面出現皺紋、凹陷，面部亦逐漸失去飽滿感4,19-21

透明質酸直達真皮下層的膠原纖維之間，立刻撐起肌膚，即現拉提緊緻18,’

CaHA透過刺激膠原蛋白纖維增生，改善肌膚內在結構^,10,13，支持自生膠原再生9,13

緊密細緻的膠原蛋白結構逐漸在肌膚內形成，帶來持續長效拉提的效果12,13,14,22,’’

HArmonyCa 持續可見的拉提效果

喚活新生膠原

由第一個星期開始2,+

與其他CaHA產品相比，HArmonyCa一星期開始已能更高度滲透入肌膚內+,^

在療程後的第2-12週，能展現更顯著及更持久的拉提效果1,*

91.6%用家見證 改善效果23-25

用家滿意度高 持續達19個月24,25,#

療程前後效果

療程前後效果

*療程效果因人而異

* Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 12 weeks.

+Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 8 weeks.

^ Extracellular matrix components such as proteoglycans and elastin.

‘Results derived from an animal model study comparing fillers.

‘’ Based on results from in vitro testing.

#Performance evaluation using the 5-point Likert Scale User Satisfaction Questionnaire.

1. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150036. Lift capacity. July 2021

2. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150040. Collagen stimulation. July 2021

3. Tortora G, Derrickson B. The Integumentary System. In: Principles of Anatomy and Physiology (15th ed). Hoboken, NJ: John Wiley & Sons Inc.; 2012. Chapter 5. p144–170. ISBN 13 978-0470-56510-0, ISBN 13 978-0470-91777-0

4. Weller RB et al. Skin Reactions to Light. In: Clinical Dermatology (5th ed). Oxford: Blackwell Science; 2015. Chapter 18. p258–266. ISBN 978-0-470-65952-6

5. Reilly DM, Lozano J. Plast Aesthet Res. 2021;8:2

6. McGrath JA and Lai-Cheong JE. Skin and its appendages. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 7. p141–161. ISBN 978-07020-5230-9.

7. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine. Clinical Study Report. July 2022

8. HArmonyCa IFU. 73960EU10. M049 V01. Revision December 2021

9. Zerbinati N, Calligaro A. Clin Cosmet Investig Dermatol. 2018;11:29–35

10. Gonzalez N, Goldberg. J. Dermatol Surg. 2019;45:547–551

12. Berlin A et al. Dermatol Surg. 2008;34(1 Suppl):S64–67

13. Gonzaga da Cunha M et al.Surg Cosmet Dermatol. 2020;12:109–117.

14. The clinical effects of CaHA can last 1–3 years.

15. Park S et al. Ann Dermatol. 2014;26:357–362

16. Wigley CB. Integrating cells into tissues. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 2. p28–41. ISBN 978-07020-5230-9

17. Borell M, et al. J Cosmet Laser Ther 2011;13:21–27

18. Hee C, et al. Dermatol Surg. 2015; 41:S373–381

19. De Boulle K et al. Dermatologic Surgery. 2018;44(11):1437–1448

20. Prendergast PM. Anatomy of the Face and Neck. In: Shiffman MA, Di Giuseppe A. (eds.) Cosmetic Surgery: Art and Techniques. Berlin: Springer-Verlag; 2013. Chapter 2. p29–45. ISBN 978-3-6422-1836-1

21. Wulc AE et al. The Anatomic Basis of Midfacial Aging. In: Hartstein ME et al (eds.) Midfacial Rejuvenation. New York: Springer-Verlag; 2012. Chapter 2. p15–28. ISBN 978-1-4614-1006-5

23. Performance evaluation using the Global Aesthetic Improvement Scale.

24. Allergan Aesthetics. Data on File. INT-HAR-2150007. HArmonyCa Lidocaine. Clinical Study Report. March 2021.

25. A post-marketing clinical follow-up of safety and performance of HArmonyCa (N=162).

隨年齡增長，膠原蛋白、彈性纖維及透明質酸加快流失^3-5，令皮膚逐漸變薄，失去結構、彈性和柔軟度，缺乏豐盈感和支撐力，出現皺紋和鬆弛下垂⁶。

透過刺激纖維母細胞，促進膠原蛋白自我再生^9,11-13

新生膠原令真皮層增厚，從而改善肌膚結構並緊緻肌膚，帶來漸進而持久的拉提效果^13,14

完全可與身體相容和被分解¹¹

肌膚細胞外基質的結構成分^15,16

結合透明質酸的彈性和凝聚力來達致拉提肌膚的效果^17,18

安全耐受性良好¹⁵

隨年紀增長，肌膚表面出現皺紋、凹陷，面部亦逐漸失去飽滿感^4,19-21

透明質酸直達真皮下層的膠原纖維之間，立刻撐起肌膚，即現拉提緊緻^18,’

CaHA透過刺激膠原蛋白纖維增生，改善肌膚內在結構^{^,10,13}，支持自生膠原再生^9,13

緊密細緻的膠原蛋白結構逐漸在肌膚內形成，帶來持續長效拉提的效果^{12,13,14,22,’’}

由第一個星期開始^2,+

與其他CaHA產品相比，HArmonyCa一星期開始已能更高度滲透入肌膚內^{+,^}

在療程後的第2-12週，能展現更顯著及更持久的拉提效果^1,*

91.6%用家見證改善效果^23-25

用家滿意度高持續達19個月^24,25,#

^{* Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 12 weeks.}

^{+Results from a pre-clinical animal study of HArmonyCa with results demonstrated over 8 weeks.}

^{^ Extracellular matrix components such as proteoglycans and elastin.}

^{‘Results derived from an animal model study comparing fillers.}

^{‘’ Based on results from in vitro testing.}

^{#Performance evaluation using the 5-point Likert Scale User Satisfaction Questionnaire.}

^{1. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150036. Lift capacity. July 2021}

^{2. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine INT-HAR-2150040. Collagen stimulation. July 2021}

^{3. Tortora G, Derrickson B. The Integumentary System. In: Principles of Anatomy and Physiology (15th ed). Hoboken, NJ: John Wiley & Sons Inc.; 2012. Chapter 5. p144–170. ISBN 13 978-0470-56510-0, ISBN 13 978-0470-91777-0}

^{4. Weller RB et al. Skin Reactions to Light. In: Clinical Dermatology (5th ed). Oxford: Blackwell Science; 2015. Chapter 18. p258–266. ISBN 978-0-470-65952-6}

^{5. Reilly DM, Lozano J. Plast Aesthet Res. 2021;8:2}

^{6. McGrath JA and Lai-Cheong JE. Skin and its appendages. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 7. p141–161. ISBN 978-07020-5230-9.}

^{7. Allergan Aesthetics. Data on File. HArmonyCa Lidocaine. Clinical Study Report. July 2022}

^{8. HArmonyCa IFU. 73960EU10. M049 V01. Revision December 2021}

^{9. Zerbinati N, Calligaro A. Clin Cosmet Investig Dermatol. 2018;11:29–35}

^{10. Gonzalez N, Goldberg. J. Dermatol Surg. 2019;45:547–551}

^{12. Berlin A et al. Dermatol Surg. 2008;34(1 Suppl):S64–67}

^{13. Gonzaga da Cunha M et al.Surg Cosmet Dermatol. 2020;12:109–117.}

^{14. The clinical effects of CaHA can last 1–3 years.}

^{15. Park S et al. Ann Dermatol. 2014;26:357–362}

^{16. Wigley CB. Integrating cells into tissues. In: Standring S et al. (eds.) Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed). Elsevier; 2016. Chapter 2. p28–41. ISBN 978-07020-5230-9}

^{17. Borell M, et al. J Cosmet Laser Ther 2011;13:21–27}

^{18. Hee C, et al. Dermatol Surg. 2015; 41:S373–381}

^{19. De Boulle K et al. Dermatologic Surgery. 2018;44(11):1437–1448}

^{20. Prendergast PM. Anatomy of the Face and Neck. In: Shiffman MA, Di Giuseppe A. (eds.) Cosmetic Surgery: Art and Techniques. Berlin: Springer-Verlag; 2013. Chapter 2. p29–45. ISBN 978-3-6422-1836-1}

^{21. Wulc AE et al. The Anatomic Basis of Midfacial Aging. In: Hartstein ME et al (eds.) Midfacial Rejuvenation. New York: Springer-Verlag; 2012. Chapter 2. p15–28. ISBN 978-1-4614-1006-5}

^{23. Performance evaluation using the Global Aesthetic Improvement Scale.}

^{24. Allergan Aesthetics. Data on File. INT-HAR-2150007. HArmonyCa Lidocaine. Clinical Study Report. March 2021.}

^{25. A post-marketing clinical follow-up of safety and performance of HArmonyCa (N=162).}